淋巴结皮质
Cortex nodi lymphoidei
- 相关用语: 皮质
定义
淋巴结皮质是启动免疫应答的关键区域。它主要由淋巴样组织构成，包含密集排列的淋巴细胞，以B细胞为主，这些细胞组织成称为淋巴滤泡的结构。在免疫应答过程中，这些滤泡可发育形成生发中心，B细胞的增殖、分化及体细胞超突变均在此处发生。
皮质的另一特征是由成纤维网状细胞（FRC）及细胞外基质成分构成的网络，形成支持免疫细胞迁移与相互作用的网状支架。该网络促进初始T细胞及抗原提呈细胞（如树突状细胞）的移动，从而启动适应性免疫应答。[1-3]
皮质内存在高内皮微静脉（HEV），允许循环淋巴细胞进入淋巴结。皮质与副皮质区不同，后者主要含T细胞；亦有别于髓质，髓质含有髓索和髓窦。[4-6]
參考資料
1.Spatial and Molecular Organization of Lymph Node T Cell Cortex: A Labyrinthine Cavity Bounded by an Epithelium-Like Monolayer of Fibroblastic Reticular Cells Anchored to Basement Membrane-Like Extracellular Matrix.Kaldjian EP, Gretz JE, Anderson AO, Shi Y, Shaw S.International Immunology. 2001;13(10):1243-53. doi:10.1093/intimm/13.10.1243.
2.Cords, Channels, Corridors and Conduits: Critical Architectural Elements Facilitating Cell Interactions in the Lymph Node Cortex.Gretz JE, Anderson AO, Shaw S.Immunological Reviews. 1997;156:11-24. doi:10.1111/j.1600-065x.1997.tb00955.x.Leading Journal
3.A Novel Reticular Stromal Structure in Lymph Node Cortex: An Immuno-Platform for Interactions Among Dendritic Cells, T Cells and B Cells.Katakai T, Hara T, Lee JH, et al.International Immunology. 2004;16(8):1133-42. doi:10.1093/intimm/dxh113.
4.Structure and Function of Rat Lymph Nodes.Ohtani O, Ohtani Y.Archives of Histology and Cytology. 2008;71(2):69-76. doi:10.1679/aohc.71.69.
5.Normal Structure, Function, and Histology of Lymph Nodes.Willard-Mack CL.Toxicologic Pathology. 2006;34(5):409-24. doi:10.1080/01926230600867727.
6.Compartmentalized Multicellular Crosstalk in Lymph Nodes Coordinates the Generation of Potent Cellular and Humoral Immune Responses.Poirot J, Medvedovic J, Trichot C, Soumelis V.European Journal of Immunology. 2021;51(12):3146-3160. doi:10.1002/eji.202048977.
