Lips
Labia oris
Definition
The lips (labia oris) are mobile, fibromuscular folds that establish the anterior boundary of the oral cavity and surround the rima (oral fissure).
Composition
Moving from the external to the internal surface, the lips are structurally composed of:
External layer: Skin
Intermediate layer: The Orbicularis oris muscle, the labial vessels, nerves, areolar tissue, adipose tissue (fat), and numerous small labial salivary glands.
Internal layer: Mucous membrane
In the midline, the internal mucous membrane of each lip reflects onto the corresponding gum, forming a structural fold of mucous membrane known as the frenulum. Notably, the upper labial frenulum is typically larger than the lower.
Functions
The lips are important in speech, facial expression, mastication, and maintaining oral competence.
Innervation
The upper lip receives sensory innervation from the infraorbital nerve (CN V2), while the lower lip is supplied by the mental nerve (CN V3). Motor supply to the lip muscles is provided by the facial nerve (CN VII).
Vasculature
Arterial supply is mainly through the superior and inferior labial branches of the facial artery.
Lymphatics
Lymphatic drainage of the upper lip is mainly to the submandibular lymph nodes, whereas the central lower lip drains to the submental nodes.
References
Kamrani P, Sadiq NM. Anatomy, Head and Neck, Oral Cavity (Mouth) [Updated 2023 Aug 14]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan. Available from: https://www.ncbi.nlm.nih.gov/books/NBK545271/