Subiculum

Subiculum is part of the S-shaped hippocampal formation, along with the dentate gyrus and the hippocampus proper. It is buried within the medial temporal lobe, forming the floor of the inferior (temporal) horn of the lateral ventricle. The subiculum lies close to the CA1 region of hippocampus and continues inferiorly with the parahippocampal gyrus.

With regards to its neuronal input, the subiculum receives afferent fibers from CA1 region of hippocampus and entorhinal cortex (anterior part of the parahippocampal cortex). With regards to neuronal output, CA1 fibers (originally received from hippocampus) are projected out of the subiculum via the fornix. In addition, subiculum subserves an important interlinking role by receiving input fibers from several other brain structures and projecting them to the entorhinal cortex.